Tag: Pangolin Immunity

  • A Pangolin Prayer – For World Pangolin Day 2021

    Exactly one year ago, I posted a blog for World Pangolin Day 2020, calling attention to the illegal Pangolin trade and the awful exotic animal market demand. Since then, I’ve spent time reading what I can find about Pangolin physiology and immunology, and progress in the challenging quest to discover the origins–and plot a prehistory of Sars Cov-2.

    Recent studies from the reputable, Francis Crick Institute, have raised the probability that the Pangolin is an intermediary species, or viral bridge between Bat Coronaviruses and Sars Cov-2 in Humans.

    Further research on the Bat Pangolin Human (cross-species transmission) plus recent papers on Mink mutations, and the flurry of new studies on the Human variants (the so called Kent/UK variant, South African Variant and the Brazilian variant) are all worthy of study. Sure, it’s a heavy load to digest. I can’t pretend to understand all of the findings, however one thing is crystal clear to me since February 2020, unless all nations review their relationships with animals and farming practice and the climate, immediately, novel pandemics will continue. I agree with Sujit:    
    “A post-pandemic historiography will surely be interdisciplinary, with critical, philosophical and collaborative engagement with scientists.–Sujit Sivasundaram, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717365/

    I urge you all to read the captivating, brilliant paper by Sujit Sivasundaram, a most detailed and broad, respectful overview of this remarkable creature and it’s reverence in traditional Chinese culture. Yes, go ahead, study the Pangolin in the context of virology and immunology and the possible–zoonotic leap–but also try to take a moment to consider their bigger picture, the pre-history culture, language art and folklore of these creatures. This context is important for discussions with any who claim Sars Cov-2 was made in, or escaped from a laboratory. Nobody has 100% certainty on the origins of the Sars Cov-2, however, like most things in history it’s down to a complex of origins.

    Something that struck me, when reading Sujit’s paper, is the respectful chant that the Pangolin poachers said aloud before killing one. This reflects other aboriginal and indigenous native people’s hunting traditions and prayer. In each, some kind of offering in word or deed or symbol is directed to that living thing which is killed to sustain them and their tribe. I consider the chant as a kind of–Lords Prayer–but in this case to the Pangolin gods, keep in mind that the traditional Chinese Pangolin poachers infused their chants with humour and puzzling poetic ambiguity. Here’s updated reverent chant for 2021, although I don’t intend to kill and eat any Pangolin.

    Pangolin Prayer
    Oh Pangolin, dear Pangolin
    I don’t want your meat
    Let’s walk under starlight
    Through mountains dancing feet
    Oh Pangolin, sweet Pangolin
    All horny and well armed
    Scales for immunity
    Balanced, unharmed
    Kaballavā, mulkodhu
    valdaranayā, æyā
    Forgive us lord Pangolin
    Please accept this prayer

    Perhaps we can extend these chants and poems (don’t call em’ roasts or toasts) to Bats and to Mink? Join me at my patreon project and help mutate these sacred chants into full blown audio/visual variants/odes.

    –Steve Fly


    “Despite the best efforts of scientists to understand the mechanisms through which this virus originated across species, the role of the historian is also critical in understanding the ‘spill-over’ of diseases, for the transference of zoonotic diseases now occurs more rapidly because of the way humans have altered nature over centuries. The mammalian orders that carry the vast majority of zoonotic diseases are rodents, bats and primates. Among the anthropogenic drivers of this transmission are human domestication of animals, human encroachment into habitats high in wildlife biodiversity, and the hunting of wild animals.18 Additionally, large-scale industrial farming is a problem because it produces genetically similar populations across which disease can spread quickly.” — Sujit, The Human, The Animal and the Prehistory of COVID-19.


    The question remains on how the pangolins became infected initially. Could it have been in their natural Southeast Asian environment, before being captured? The discovery of a new virus close to SARS-CoV-2 in bats in Cambodia supports this hypothesis, as Rhinolophus bats and pangolins can meet, at least occasionally, in caves in Southeast Asia. This strengthens the hypothesis that pangolin trafficking is responsible for multiple exports of SARS-CoV-2-like viruses to China.–https://nationalinterest.org/blog/reboot/virus-similar-covid-19-was-present-cambodia-early-2010-177739


    “For much of last year it spread quietly, then a cluster of patients infected with the virus carrying a H69/V70 deletion appeared in Denmark. This mutation was appearing in a version of the virus that was being passed from mink on farms to humans. While analysis showed the virus had mutated slightly to become more infectious to the animals, some early data suggested it was also less sensitive to antibodies contained in the blood serum of patients who had recovered from Covid-19.–https://www.bbc.com/future/article/20210127-covid-19-variants-how-mutations-are-changing-the-pandemic


    “The South China tiger (Panthera tigris amoyensis)and the Chinese pangolin(Manis pentadactyla),a scaly anteater, occupy ancient and important niches in the biologically diverse ecosystems of Chinese folk cosmology. Both animals are believed to have mysterious magical power and high medicinal value, and both are now under state protection.–https://www.jstor.org/stable/j.ctt6wr4f1


    “In Chinese legend pangolins are said to travel all around the world underground, and in the Cantonese language the name for pangolins translates to “the animal that digs through the mountain,” or “Chun-shua-cap,” which translates to “scaly hill-borer.”–http://www.edgeofexistence.org/species/chinese-pangolin/

  • Corona Cypher – First Thought Best Thought

    Corona Cypher – First Thought Best Thought

    Hi, in contrast to my blog yesterday, I’ve let my words fly in a first-thought best-thought cypher, to imagine a vaccination potion full of verbs and motion.

    Soul vaccination,
    All across the nation people been catchin’ honkypox (Honkypox)
    When you get the notion,
    Tower’s got the potion – you might look in to set yourself in motion.
    Soul Vaccination, Tower Of Power (What Is Hip)

    Patience patient paint that paradise
    Dr immuno’ flow help you throw the dice, thrice
    Who know what you think you know, let it go
    Let it flow, spring come lift the light plant and grow
    Wash em’ lift it up and push it up keep vibes up high
    Planet spinning on its axis, rapid climate renewal
    Quick death of toxic stock in fossil fuel?
    Banking crash human race nineteen meter dash
    French minister of culture cumming out with the rash
    Johnson and Trump eye the cash king, econo-money over people?
    Putin wins republican tory vote
    Billions of particles dormant in throat
    The vote spoiled crops and oats
    Stop the blame game, same game, stop the wheels
    Not with a bang but with a whimper
    Better get a woolly jumper, spring has sprung
    Equinox 2020 indoors tracking thought spores up walls
    Banish fears and move forward like new years
    Watch the fossil fuel weasels fight in their hole
    Watch the Eagle, the Bear, The Unicorn and Vulture
    Reach for the bowl, good for the soul and the journey
    Euthanasia king now fight kapow
    Hemp futures, plant a seed, that’s what we need
    Fight greed with surplus, forests mighty string
    Food fibre fuel, come on fool…I’ll be your mule
    Grow that hemp for victory
    To fight the king 19 viruses, microbial and global
    Use your head heart and irises
    Look, listen, shine glisten
    Now be that change, stay in range, set your sights
    Like Noah we move tongues to a new dark 3.0 cypher
    “Oh no…” but stand up and face the music, don’t go
    Be the forward thinking solutions oriented one
    Like, ride your bike
    Take a hike
    Don’t touch that rail, feed the poor and make them  strong
    Look after your prisoners,
    Hold your officials to their word
    Wash your hands, flush the turd
    Attention to word mind body
    You’re not going to die be strong, hold on buddy
    Here’s a hand not a head-in the sand
    Here’s a jazz solo, a new album, a brand new band
    Over air, sea and land, in hope you better understand
    Rhyme can unleash endorphins
    And endolphins swim with dolphins
    Prose vaccination for experimentation
    Try it, don’t buy it grow your own
    Put down that toilet roll put down your phone
    Wash your hands and put em’ in the air
    Wave em’ like you care
    Mash on son, mash on with compassion
    Get your grow on, go on
    Earth and humanity needs you and what you grew
    Make a new garden crew
    Do what you need to do to prevent flu
    Stay high, fly, CBDJ “Hi,”
    Feed your immune system with funny thoughts
    Play mind games and put out doubt with flames
    Quote facts and peer-reviewed names to reignite
    Each and every night unravel your talk tapes mi’ mates
    More toxic than J.P Morgan
    Monsanto and a five-year-old bag of rotten potato
    From the get-go King Virus by contamination
    Like the four horseman in the Tesco lasagna
    Animal traffick led to…
    Pick up the mic and go endemic to prevent panic
    With a goat, sceptre, and pot plandemic
    Slammdemic dem
    Murder virus sound
    Kill that virus sound
    Slamm Dem Pandem Mandem standin’ firm
    Throw water on it, fire, earth, blow it away?
    No gun or bomb can shoot this King dead
    Spreading like all memes trending at once, widespread dread
    All Ornette Coleman solo’s at once
    A William Gibson meets John le Carre’ finale’
    Humanity run off down the motorway like a headless Pangolin
    Mis-identified as link between animals and humans (My Bad!)
    News and gov still manglin’
    Vultures anglin’
    Life lines be danglin’
    Who’s who is handling?
    Ching Ming….CHING MING
    What good governance?
    Utterance, for a dollar, do a Johnson trap dance
    Pulling out while Cummings keeps on Cumming
    In Putin’s mouth
    Snivilization slouches further south
    No worries, it’ll soon come around
    Table turn around sounds fresh and loud
    Disperse to move the crowd, us discoronians stick apart
    Stay one meter away and claim your space
    Make your ritual space in that place
    Surround yourself with good omens
    Cleanse banish power up be here now
    Wash your hands and then touch your face
    Speak with sincerity, move with a trellis of lace, with grace
    Rhyme to climb into the head and bring relief
    Boost your immune system with some sexual relief
    No tissue, use a handkerchief
    Turn grief to a new leaf, good greaf?
    Sacrifice for greener futures
    That healthy planet for the young the dinosaurs refused?
    A death sentence for business
    The end of the dinosaur age is messy
    Goodbye T-Rex, goodbye Nessy
    Oil and fossil fuel industry made dust, past history
    Toxic debts and bonds fall like towers unwashed money
    Another bust boom bust boom!
    Evidence capitalist governmints made of sand-men
    Who do you trust?
    World market kept up by tent poles made of jelly and marzipan
    International unrestricted finance capitalism
    Pandemic running loose infecting humans for millennia, check it
    If Language is a virus from outer space so is money, burn it
    A Pangolin Bat broth dissolved trillions
    Gobble gobble gobble they earned it
    Hairs on the arms of billionaires and millionaires flare
    You can imagine them looking into space
    From a Yacht, that stare
    No blame, stop hating, we need to come together and stick apart
    And keep masterbating
    Wankers against the second come-king
    Our leader’s Russel Brand and Milley Ray Cirus
    You’re gonna need pliers to get me out of bed
    Stuck to the sheets by my leaky prik-stick spread
    Who’s the illest now?
    Beat the virus
    Go wireless and tell a tireless solo choir-less let’s go
    Don’t fight forces use them,
    Learn to love the illness and embrace darkness in fullness
    And shine light, illuminate, stimulate sexdrive
    To produce white blood cells
    Mind body speech, word sound power, wash pray spit and shower
    Cleanliness is next to holiness, be the pollen and the flower
    Dethrone King virus and lock it away in a tinder box.
    Not from terrorists but bats and pangolin
    Pang, pang, pang, pang, with a pang and with a whimper
    Solidarity with all in discomfort from hunger loneliness
    Suffering from Corvid19, heartbreak or regular flu
    My thoughts and virtual arms just dropped the mic to hug you
    Fight back with A G C and T
    It’s only about 8 Kilobytes, put em’ up,
    Language is the key, break the spell do it well, duck, weave, duck duck
    invocation not required, they’re all around touch taste sound smell
    On earth and inner neurological spaces, as in heaven as in hell
    Places to bottle up solutions and write new potions
    To kill the King Virus and bring hope to nations
    Yes we can figure out preventative medicine
    Starting with high dose sessions of psilocybin
    Stay high and happy, positive, keep vibing
    Calling all gods and goddesses worldwide and beyond
    From the Compton Length to Hubble’s Red-Shift
    Under mountain, glacier and pond
    Give us a hond’
    Every quantum super-computer and solid-state entity
    Each and every discarnate spirit, ghost, an angel hear me
    There’s no part of me that’s not of the gods, you neither
    What are the odds, really, what are they cuddlies?
    Who’s the patient zero breeder?
    May the researchers find luck and perspire little
    May the ancestor animal and insect spirits rise from this spittle
    And bring the entheogenic dimension of love to our eyes
    Love all the people, the plants and the flies
    Take rest on your low points, take flight on your highs
    Do art and dance, sing keep an eye out for all
    Up there on the ceiling and above the roof from the floors to the wall
    Keep death on a pale horse at bay
    The return of the King
    Who would want such a thing
    Who wears the crown of thorns
    What religious leader can end all wars
    Biological peacemaker or lifetaker?
    Poems dark turn toward scripture, tongues burn
    A crown of thorns corona
    The second coming of Christ, Koronagain
    Judgement Day Coronopalypse
    Convictions make convicts?
    If you wish to put it that way and let it past your lips?
    I say neigh, not on my watch, not tomorrow and not today
    Pick any scripture, any month, any day and fire away and say
    Any event from the last five years signifies end times
    Judgement day, the apocalypse
    World populist political surge and 2008 banking heist scourge
    Economic corporate fascist free-reign, acid rain, Bottcher con main
    Climate and environmental lies, deceit…
    Take your pick…from the familiar terrain, stay rational
    Don’t lose your nerve
    Just cuz’ Christ wore a crown of thorns
    And his mythical return to judge
    Humanity does not mean
    The Jesuspect Christereotype is guilty, does it?
    Cleanliness next to holiness
    From animal kingdom hunted and trafficked
    To near extinction by an appetite for meat and status, meat death
    Better get in touch with your immune system, direct line please
    Hello, hi, hello, can you hear me, this is…..
    Hello, hey, are you there, this…this is steve”
    As I said, take those magic mushrooms, get up, get out of bed
    Stand up be strong lead the way to health and fitness, break bread
    Get ready to fight and to encourage others
    Rhyme with reason be tough
    Be brave write it out, fears and cheers together
    The light and dark Escher effect
    What happened to bird flew and wine flu?
    Word flew, bird said, word stew, me brew tea brew
    The vaccine is at the bottom of the mushroom teacup
    With chunks of some Amanita or other?
    Use mushrooms for good god damn it
    Within the poison may lie the cure?
    I’ll smoke spliff an’ listen to Rob Smiff
    Love you, stay safe.

    –Steve Fly Agaric 23.

    Some links…

    See Also:
    https://www.jstage.jst.go.jp/article/antibiotics1968/40/6/40_6_904/_article/-char/ja/

    https://pdfs.semanticscholar.org/f685/c5844a712ce145a5366c97c42aee4c90deac.pdf

    https://foreignpolicy.com/2020/02/27/coronavirus-south-korea-cults-conservatives-china/

     

  • Pangolin Didn’t Kill Itself: For World Pangolin Day 2020

    Pangolin Didn’t Kill Itself.

    Since news of the novel coronavirus spread late last year, I was struck by claims that the virus originated in snakes and/or bats. In my minds eye I quickly saw the image of a brew in a cauldron, “The eye of a newt and the toe of a frog etc..” This gut reaction led me to consider chemistry and microbiology based upon some folkloric themes.

    Snakes and bats have a wide and long history in folklore, and associated in popular culture with poison. Recent studies rebuked claims that Coronavirus was transferred to humans by snakes and/or bats, and instead proposed the missing link is a creature called the Pangolin, in Greek it roughly translates to Horny Scale, in Malay, “something that rolls up”. 

    Until this latest theory for the critter responsible for spreading the novel coronavirus to humans, I knew nothing of the Pangolin, and so discovered all manner research papers and physiological attributes that I would like to share (SEE BELOW) I’ve been disappointed with how news channels and organizations cover the outbreak and hope to share at least one fact that will inspire your own research, perhaps write of what you discovered. 

    My goal is to get to imagine you have a team of researchers in a laboratory. I don’t think it’s too far off the mark to look at the Pangolin and it’s place in genomic studies and its use in studying the immune system of mammals.  Plus it’s mention in folkloric traditions. Consider that Pangolin scales are in high demand around the world for their flesh and scales, for both eating and for medicine.

    The Pangolin is the ONLY scaled mammal in the animal Kingdom, it is noteworthy that it’s scales evolved due to high susceptibility to infection. The armour is a layer of protection when under attack or sleeping. The scales are made of keratin, which human nails and hair are also made, some have said that you can get health benefits by eating toe-nails. The religious-like, toxic belief that certain exotic animal parts will bring good luck, virility and other narcissistic benefits, is a big problem. Pangolin meat is very expensive, and not for the poor working cass.  

    Pangolin were not registered as being sold at the Wuhan market, yet witnesses have said that they were bought and sold there, and kept in unhygienic conditions, they are susceptible to infection.
    Do a quick search Pangolin + Scholar and browsethe articles. The Pangolin is the number ONE most trafficked critter in the global trade of illegal critters. A quick news search will turn up multiple stories of Pangolin busts on par with drug busts, in their estimated value. Who knew that the critter suspected of being the missing link between spreading the virus between animals and humans was also one of the most sought after critters on the black “exotic pet” market?

    To add insult to injury for the innocent anteater, their natural habitat is being destroyed, resulting in species of Pangolin classified critically endangered. This threat of extinction makes the black market thrive.
    In Zimbabwe, folk legend says that anybody who kills Pangolin will have bad luck, if only we would have enforced the laws protecting these critters from poaching earlier and kept in step with tribal wisdom.

    Although the breakout is sourced to Wuhan, and a specific market place, the bigger picture reveals a global network of players, traffickers, customers and middle-men who make up the supply and demand for Pangolin and other exotic animals. This paper reveals that Germany plays a large role in Pangolin smuggling operations. It seems the Germans have a taste for exotic pets and animals, and a worldwide customer base.

    This trafficking must stop immediately for the sake of all critter-kind and for the endangered species. Like trafficking in arms, drugs and sex, the traffick of Pangolin are responsible for a large part of the trouble around the planet today. The greedy don’t care if it’s guns, heroin, teenage-girls or lizards, deregulation helps them thrive.

    Studies show the mistreatment of the Pangolin leads to a higher probability of infection, which brings us back to black markets, illegal trafficking and inhumane treatment. The mucous of the Pangolin, and it’s very long tongue, and unique mouth muscles are worthy of study. Their insectivore diet of ants, termites and small worms are processed by the Pangolin, which lead to a deeper understanding of chemical symbiosis.

    I sincerely hope a cheap and easy to manufacture vaccine is discovered soon. If indeed, the Pangolin is the culprit, may they be treated with respect and may consideration be given to the link between pandemics and animal trafficking for profit.

    THE ROLE OF GERMANY IN THE ILLEGAL GLOBAL PANGOLIN TRADE
    https://www.sciencedirect.com/science/article/pii/S2351989419303233

    DID PANGOLINS SPREAD THE CHINESE CORONAVIRUS TO PEOPLE?
    https://www.nature.com/articles/d41586-020-00364-2

    PANGOLIN GENOMES AND THE EVOLUTION OF MAMMALIAN SCALES AND IMMUNITY.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052048/

    “As an evolutionary consequence of being covered by scales, it is plausible that the pangolin immune system evolved differently than in other mammals. For example, genes such as IFNE, a unique interferon exclusively expressed in skin epithelial cells and inner mucosa-protected tisssues (e.g., lung, intestines, and reproductive tissues), establish a first line of defense against pathogens in other placental mammals (Day et al. 2008; Ponten et al. 2008; Xi et al. 2012; Fung et al. 2013; Demers et al. 2014; Uhlen et al. 2015). Interferons (IFNs) are a cluster of highly conserved gene families that encode for cytokines expressed by host cells for communication between cells, leading to the activation of the immune system in the presence of pathogens (De Andrea et al. 2002; Fensterl and Sen 2009). Strikingly, the single copy intronless IFNE gene is pseudogenized in both pangolin species (confirmed by Sanger sequencing; sample size = 8) but is intact in 71 other mammalian species”

    TRADITIONAL-MEDICAL KNOWLEDGE AND PERCEPTION OF PANGOLINS (MANIS SPS) AMONG THE AWORI PEOPLE, SOUTHWESTERN NIGERIA.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179697/

    Here’s a useful guide on how to help, by way of deep learning.

    –Steve Fly