23 dreams to introduce 23 condensed chapters of reflections on time-space spent well in England, America and the Netherlands–(2000-2011). The Spore Of The Words, or World Piss or Shannanigums Wave, juxtaposes a selection of prose from Fly’s note-books, blogs and novels into a big soup, brewing since 2006 and presented here in it’s 45th incarnation, edited for the special date 11/11/11. Re-njoy.
–Steve Fly
Spore Of The Words
by Steven Pratt
Link: http://a.co/g5uev86
Finally, after more than 20 years, i registered a domain and paid for a wordpress package.
Now, and in the coming weeks and months i’ll seriously update and add-to this site, and attempt to link up all my other works, and collaborations from around the web.
Thanks for checking in. Please leave a note or any suggestions for inclusion. Write on.
–Steve Fly
Bucky Fuller, another renowned student of general semantics, named such thinkers “comprehensivists.” Fuller was himself an iconic representative of the comprehensivists.
http://korzybskiinstitute.blogspot.co.uk
Fattening Blogs For Snakes (a John Sinclair blog)
Music, radio shows, reviews, movies, photography, flyers, poetry, art, painting. Orbiting the constellation of John Sinclair.
Kept by steve fly agaric 23.
RAWIllumination.net: Talking with Steve “Fly Agaric 23” Pratt: Few, if any, people have been more energetic in setting up Internet sites to promote the works and though of Robert Anton Wilson than Steve …
Who could resist a new book about the celebrated, notorious “arch-conjuror of England,” Dr. John Dee (1527-1609)? A contemporary of Queen Elizabeth I, Dee possessed what was probably the finest private library in the country. He lived near the Thames in a house with a name that any Gothic novelist would steal in a minute: Mortlake. As a young man, he was a pupil of Gerard Mercator (whose maps are still famous) and studied the works of all the most notable alchemists and natural philosophers of Europe, including Paracelsus, Raymond Lull, Johannes Trithemius and Henry Cornelius Agrippa. Dee might even have met Giordano Bruno, who, during a visit to England, joined the circle of their mutual friend, the occult-minded poet Sir Philip Sidney. (In 1600, Bruno was burned at the stake, ostensibly for his heretical beliefs about the nature of the universe.) In 1584, this English wizard even made a laborious journey to Rudolf II’s Prague, the center for astrological and hermetic research in the 16th century — in essence, the capital of magic. http://www.washingtonpost.com/entertainment/books/the-arch-conjuror-of-england-john-dee-by-glyn-parry/2012/06/06/gJQAOGOUJV_story.html
Galileo was only placed under house arrest because of his “repentance,” but others such as Michael Servetus (1511-1553) and Giordano Bruno (1548-1600) were burnt at the stake. http://www.thenews.com.pk/Todays-News-9-113602-Lessons-from-the-Galileo-affair
Everyone is charmed when we chance upon our first Fly Agaric, the iconic red and white seat of many a storybook fairy or elf. Just then the sky darkens, the mother and father of all downpours leaving no shelter. Waterproofs are useless, we can only head back to the hotel? http://www.irishexaminer.com/lifestyle/grow-wild-in-the-country-195283.html
Go to: Muscarinic receptors in the lung In the lungs, anticholinergic compounds block muscarinic receptors on airway smooth muscle, glands and nerves to prevent muscle contraction, gland secretion and enhance neurotransmitter release. There are five muscarinic receptor subtypes [designated M1 through M5 by the IUPHAR (Caulfield and Birdsall, 1998)] all belonging to the large family of seven transmembrane G-protein coupled receptors. In human lung (and in all animal species tested), acetylcholine induces bronchoconstriction by stimulating M3 (Figure 1) receptors on smooth muscle (Roffel et al., 1990). Although airway smooth muscle contraction is mediated by M3 receptors, the majority of muscarinic receptors on airway smooth muscle are actually M2 (Barnes, 1993). These M2 receptors contribute indirectly to airway smooth muscle contraction by limiting β-adrenoceptor-medicated relaxation through inhibition of adenylate cyclase (Fernandes et al., 1992). Glandular secretion is also mediated predominantly by M3 muscarinic receptors on submucosal cells (Marin et al., 1976; Borson et al., 1980; Phillips et al., 2002). Figure 1 Muscarinic receptors in lungs. Muscarinic receptors (MR) are present throughout the lungs and control smooth muscle contraction, gland secretion, acetylcholine (ACh) release from parasympathetic nerves and probably also inflammatory cells. Only receptors (more …) Muscarinic receptors are also present on parasympathetic nerves supplying the lungs (Fryer and Maclagan, 1984). M2 muscarinic receptors on postganglionic parasympathetic nerves (Faulkner et al., 1986; Fryer et al., 1996) limit acetylcholine release, thus providing a physiologically relevant, negative feedback control over acetylcholine release (Fryer and Maclagan, 1984; Baker et al., 1992). Blocking M2 receptors with mmuscarinic antagonists including atropine and ipratropium or using selective M2 receptor antagonists such as gallamine, significantly potentiates vagally induced bronchoconstriction (Fryer and Maclagan, 1984; 1987; Blaber et al., 1985; Faulkner et al., 1986). Neuronal M2 receptors are vulnerable, and thus their function is significantly decreased after respiratory viral infection, antigen challenge, or exposure to organophosphates or ozone (Empey et al., 1976; Aquilina et al., 1980; Fryer and Jacoby, 1991; Schultheis, 1992; Schultheis et al., 1994; Sorkness et al., 1994). They are also less functional in humans with asthma (Minette et al., 1989). Decreased function of the neuronal M2 receptors is mediated by various mechanisms including blockade by endogenous antagonists and down-regulation of receptor expression. The resulting increase in acetylcholine release is thought to be an important mechanism of airway hyperreactivity. Clinically, anticholinergic drugs are used as bronchodilators in combination with anti-inflammatory steroids in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Asthma is characterized by variable airflow limitation that is partially reversible spontaneously or with treatment. Underlying this airflow limitation is chronic inflammation that increases airway hyperresponsiveness to various stimuli (EPR-3, 2007). COPD is characterized by chronic airflow limitation that is not fully reversible. Patients with COPD can experience acute worsening in symptoms. These exacerbations are characterized by increased sputum production and shortness of breath (Rabe et al., 2007). COPD and asthma symptoms overlap; however, the most distinguishing difference between conditions is airflow limitation reversibility. This review covers the history of clinically relevant anticholinergic drugs in asthma and COPD. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085867/
DEEP SCRATCH 